The use of the dried blood spot sample in epidemiological studies

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The use of the dried blood spot sample in epidemiological studies.

The concept that capillary whole blood, obtained by heel or fingerprick and blotted on to a filter paper (Guthrie card), could be used to screen for metabolic disease in large populations of neonates was introduced in Scotland by Guthrie and Susie in 1963. Neonatal screening for phenylketonuria became nationwide in 1969/70. Since then, Guthrie card samples from two to nine day old babies have b...

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Leader The use of the dried blood spot sample in epidemiological studies

The concept that capillary whole blood, obtained by heel or fingerprick and blotted on to a filter paper (Guthrie card), could be used to screen for metabolic disease in large populations of neonates was introduced in Scotland by Guthrie and Susie in 1963. Neonatal screening for phenylketonuria became nationwide in 1969/70. Since then, Guthrie card samples from two to nine day old babies have b...

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learners’ attitudes toward the effectiveness of mobile-assisted language learning (mall) in vocabulary acquisition in the iranian efl context: the case of word lists, audiobooks and dictionary use

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the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach

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Critical sample pretreatment in monitoring dried blood spot citrulline.

BACKGROUND Plasma Citrulline concentration has been correlated to functional enterocyte mass. Dried blood spot (DBS) analysis using LC-MSMS reduces sample amount needed. We optimized DBS elution to increase precision and accuracy of DBS LC-MSMS analysis. METHOD DBS control samples were eluted in varying pH (2.2-7.0) and for varying times (15-75 min) and Cit, Arg and Orn were analyzed using LC...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1999

ISSN: 0021-9746

DOI: 10.1136/jcp.52.9.633